G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01)
Patent
CA 2501926
The present invention relates to diagnosis of neutropenia and to methods for determining susceptibility to infection. The invention also relates to methods for treating neutropenia and treating and/or preventing infections. The inventors have shown that a reduction in the levels of LL-37 in the saliva and neutrophils results in an increased susceptibility to periodontal infections caused mainly by bacteria from the normal oral flora. The present invention provides a method for determining the susceptibility of a subject to infection, which method comprises: i) providing a sample from said subject; ii) detecting any LL-37 present in said sample; iii) optionally comparing the level of LL-37 in said sample to a control. sample; and iv) determining the susceptibility of said subject to infection, wherein no LL-37 or a low level of LL-37 indicates that said subject is susceptible to infection.
Cette invention a trait à une méthode permettant de déterminer si un sujet est enclin à contracter une infection, laquelle méthode consiste (i), à se procurer un prélèvement appartenant à ce sujet, (ii), à détecter toute présence de LL-37 dans le prélèvement, (iii), à comparer éventuellement la concentration de LL-37 de ce prélèvement à celle d'un prélèvement témoin et, (iv), à déterminer la propension du sujet à contracter une infection, l'absence de LL-37 ou une faible concentration de LL-37 indiquant que ledit sujet est enclin à contracter une infection.
Andersson Mats
Boman Hans
Carlsson Goeran
Putsep Katrin
Fetherstonhaugh & Co.
Mabtech Ab
LandOfFree
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