A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 9/127 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2480408
It is intended to provide a method of constructing liposomes having a complex of a metal radioactive nuclear seed having a short half-life (for example, 99mTc) and CD encapsulated therein at a practically available radiochemical yield and purity. Namely, a method of producing liposomes having a short half- life metal radioactive nuclear seed and ethylenedicysteine (CD) encapsulated therein which comprises mixing a complex of the short half-life metal radioactive nuclear seed and N-[2(1H-pyrrolylmethyl)]-N~-(4-penten-3-one- 2)ethane-1,2-diamine and liposomes having ethylenedicysteine (CD) encapsulated therein and incubating the same is provided.
L'invention porte sur un procédé de fabrication de liposomes possédant un complexe d'une semence souche radioactive métallique de courte période radioactive (par exemple ?99m¿Tc) et de l'éthylènedicystéine (CD) encapsulé à un rendement et une pureté radiochimiques facilement disponibles. Aussi, l'invention porte sur un procédé de fabrication de liposomes possédant une semence souche radioactive métallique de courte période radioactive et de l'éthylènedicystéine (CD) encapsulé, consistant à mélanger un complexe de la semence radioactive métallique de courte période radioactive et N-[2(1H-pyrollylméthyl)]-N'-(4-pentène-3-one-2)éthane-1,2-diamine et des liposomes contenant de l'éthylènedicystéine (CD) encapsulé et à incuber ces éléments.
Arano Yasushi
Kaneko Emi
Murakami Masahiro
Amato Pharmaceutical Products Ltd.
Dennison Associates
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