A method for enhancing long-term memory in a subject and...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/10 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/02 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257074

The present invention provides for a method to enhance longterm memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.

Cette invention concerne un procédé permettant d'améliorer la mémoire à long terme chez un sujet dont l'expression du gène réagissent à cAMP est réprimée en raison de la liaison d'une protéine 2 de liaison d'élément de réponse à cAMP à une protéine ou un ADN associé à l'expression du gène réagissant à cAMP, ou aux deux. Le procédé de cette invention consiste à administrer au sujet un composé capable d'entraver cette liaison, en une quantité efficace pour entraver avec la liaison de la protéine ou de l'ADN de manière à dé-réprimer l'expression du gène réagissant à cAMP chez le sujet et améliorer de la sorte sa mémoire à long terme.

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