A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/455 (2006.01) A61K 31/00 (2006.01) A61K 31/445 (2006.01)
Patent
CA 2352964
The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. The invention further relates to pharmaceutical compositions comprising pro-NAD agents that effectively elevate intracellular NAD content. Finally, the invention relates to the method of using the pro-NAD agents to treat disorders such a s sunburn and other skin deterioration that results from DNA damage in skin cells.
L'invention concerne des méthodes d'utilisation d'agents de la pro-nicotinamide-adénine-dinucléotide (NAD), capables d'augmenter la teneur en NAD des cellules dermiques et épidermiques de la peau. Ces agents pro-NAD peuvent être administrés localement, par voie orale ou parentérale de façon à favoriser la réparation de l'ADN et d'autre réactions protectrices contre les dommages causés à l'ADN. L'invention concerne également des compositions pharmaceutiques contenant ces agents pro-NAD, qui augmentent de façon efficace la teneur intracellulaire en NAD. L'invention concerne enfin la méthode d'utilisation de ces agents pro-NAD dans le traitement de troubles, tels que les érythèmes solaires et d'autres détériorations cutanées résultant des dommages causés à l'ADN dans les cellules cutanées.
Jacobson Elaine L.
Jacobson Myron K.
Borden Ladner Gervais Llp
University Of Kentucky Research Foundation
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