A method for generating high affinity antibodies

Details A method for generating high affinity antibodies A method for generating high affinity antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/42 (2006.01)

Patent

CA 2514839

The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

L'invention concerne des anticorps monoclonaux humains à affinité élevé, notamment ceux dirigés contre des déterminants isotypiques d'immunoglobuline E (IgE), ainsi que des équivalents et des dérivés directs de ces anticorps. Ces anticorps se lient à leur cible respective avec une affinité au moins 100 fois supérieure à celle d'un anticorps parental d'origine. Ces anticorps sont utiles dans le diagnostic, la prévention et le traitement de maladies.

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