A method for generating hypermutable organisms

Details A method for generating hypermutable organisms A method for generating hypermutable organisms

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C12N 15/01 (2006.01) C12N 15/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2240609

Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation.

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