A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/21 (2006.01)
Patent
CA 2403718
The current invention relates to methods of generating immunogens that elicit broadly neutralizing antibodies which target regions of viral envelope proteins such as the gp120/gp41 complex of HIV-1. More specifically, the current invention involves using stabilizing peptides modeling the .alpha.- helical regions of the ectodomain of the HIV-1 transmembrane protein to stabilize fusion-active intermediate structures which can be used as vaccine immunogens.
L'invention concerne des procédés de génération d'immunogènes élicitant des anticorps de neutralisation étendue ciblant des zones de protéines d'enveloppe virale, telles que le complexe gp120/gp41 de VIH-1. Elle concerne, plus particulièrement, l'utilisation de peptides de stabilisation modélisant les zones d'.alpha.-hélice de l'ectodomaine de la protéine de transmembrane de VIH-1 afin de stabiliser des structures intermédiaires de fusion active qu'on peut mettre en application en tant qu'immunogènes de vaccins.
Allaway Graham P.
Wild Carl T.
Mbm Intellectual Property Law Llp
Panacos Pharmaceuticals Inc.
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