A method for in vivo selection of ligand-binding proteins

Details A method for in vivo selection of ligand-binding proteins A method for in vivo selection of ligand-binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C12N 15/01 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2115811

ABSTRACT A Method for In Vivo Selection of Ligand-Binding Proteins The application discloses a method, and kit, which enables the selection of proteins or other oligo- or polypeptides (collectively, ligand binding proteins, LBPs) which bind with high affinity to a target ligand or receptor. The method relies on the display of the LBP of interest on the surface of replicable genetic packages (RGPs) which are modified so as to be non-infective. Infectivity is restored to those RGPs displaying LBPs with high affinity for a target ligand or receptor by an infectivity mediating complex. The infectivity mediating complex comprises the ligand or receptor covalently linked to a polypeptide which brings about interaction between the RGP and a host cell. It is envisaged that the LBP of interest will belong to a genetically diverse collection of similar substances. The method therefore allows selection of substances with high affinity for target, from within a large collection of variants.

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