A method for increasing cd8+ cytotoxic t cell reponses and...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 35/14 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2542668

The present invention relates generally to the field of immunology and development of autologous vaccines. More specifically, the present invention is concerned with a method of treating autoimmune disease Multiple Sclerosis (MS) by means of immunizing patients with autologous CD8+ cells activated with fragments of Myelin Basic Protein (MBP). The present invention identifies four immunogenic MBP fragments with high binding affinity to HLA-A2 and HLA-A24 receptors and discloses how to use these fragments in preparing anti-MS vaccine.

La présente invention a trait au domaine de l'immunologie et de la mise au point de vaccins autologues. De manière plus spécifique, elle concerne un procédé pour traiter une maladie auto-immune, telle qu'une sclérose en plaques. Ce procédé consiste à immuniser des patients avec des cellules CD8?+¿ autologues activées avec des fragments d'une protéine basique de myéline (MBP). Cette invention concerne un procédé pour identifier quatre fragments immunogènes présentant une grande affinité de liaison aux récepteurs HLA-A2 et HLA-A24, ainsi que l'utilisation de ces fragments pour préparer un vaccin luttant contre la sclérose en plaques:

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