C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/68 (2006.01) C12N 9/22 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2749396
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryot-ic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermore, it relates to nucleic acid sequences exhibiting a reduced number of RNase L cleavage sites as well as to the proteins translated from such sequences.
La présente invention porte sur un procédé pour l'augmentation de l'expression d'une protéine dans des cellules, de préférence dans des cellules eucaryotes, par réduction du nombre de sites de coupure par L'ARNase L dans la région codante et/ou non codante de la séquence d'acide nucléique de ladite protéine. En outre, l'invention porte sur des séquences d'acide nucléique présentant un nombre réduit de sites de coupure par l'ARNase L, ainsi que sur les protéines traduites à partir de telles séquences.
Gowling Lafleur Henderson Llp
King Faisal Specialist Hospital And Research Centre
Terramark Markencreation Gmbh
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