C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C40B 10/00 (2006.01) C40B 40/08 (2006.01) C40B 50/18 (2006.01)
Patent
CA 2584453
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity. The invention enables the in vitro evolution of nucleic acids by repeated mutagenesis and iterative applications of the method of the invention.
Griffiths Andrew
Tawfik Dan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Medical Research Council
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