C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07K 14/395 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2226394
In an effort to determine the precise events taking place during telomere replication in yeast, the Applicant realized that mutations in either gene encoding the yeast homologues of the Ku-protein lead to an altered terminal DNA structure. In cells lacking Ku, telomeres have an overhang of 50-90 bases of the 3'-end even in cells outside S-phase. In addition, using an epitope tagged version of Yku80p and an in vivo crosslinking protocol, DNA fragments containing telomeric repeats could be immunoprecipitated from cell free extracts. These results suggest that the Ku-protein plays a direct role in maintaining a normal DNA end-structure on yeast chromosomes, conceivably by functioning as a terminus-binding factor.
Gravel Serge
Wellinger Raymund
Smart & Biggar
Universite de Sherbrooke
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