A method for inhibiting attachment of h. influenzae to human...

Details A method for inhibiting attachment of h. influenzae to human... A method for inhibiting attachment of h. influenzae to human...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A23C 9/20 (2006.01) A23L 1/305 (2006.01)

Patent

CA 2234664

A method is provided for inhibiting the attachment of H. influenzae to human cells, such as pharyngeal cells, by contacting the bacilli with phosphorylated recombinant human .beta.-casein that have at least 3 phosphate groups. A product containing phosphorylated recombinant human .beta.-casein may be a liquid enteral nutritional product such as infant formula. The enteral nutritional product may be used for the prevention and treatment of otitis media in infants. The phosphorylated recombinant human .beta.-casein may also be administered as a throat spray or used in nose drops or a spray.

Procédé permettant d'inhiber la fixation de H. influenzae sur des cellules humaines, telles que les cellules pharyngées, consistant à mettre le bacille en contact avec de la .beta.-caséine humaine phosphorylée de recombinaison possédant au moins 3 groupes phosphate. Le produit contenant de la .beta.-caséine humaine phosphorylée de recombinaison peut être un produit nutritionnel entéral liquide tel que du lait maternisé. Ledit produit nutritionnel entéral peut être utilisé pour prévenir et traiter l'otite moyenne chez les nourrissons. La .beta.-caséine humaine phosphorylée de recombinaison peut également être administrée sous forme d'aérosol pour la gorge ou utilisée dans des gouttes ou des aérosols pour le nez.

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