A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 9/04 (2006.01) C07K 14/47 (2006.01) C07K 17/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2349758
The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sarcoplasmic reticulum Ca2+ ATPase (SERCA2a) within cardiomyocytes. In addition, a means is provided for the transport of such therapeutic agents into the cytoplasm and nucleus of cardiomyocytes.
La présente invention concerne une technique de traitement de l'insuffisance cardiaque par l'utilisation de petits complexes peptidiques et de protéines recombinantes qui permettent d'accroître la contractilité du coeur défaillantt de réduire la tension artérielle chez l'individu sujet à l'hypertension, en inhibant l'interaction du phospholamban et de la Ca?2+¿ ATPase (SERCA2a) du réticulum sarcoplasmique dans les cardiomyocytes. En outre, l'invention présente un moyen permettant de transporter ces agents thérapeutiques dans le cytoplasme et dans le noyau des cardiomyocytes.
Chien Kenneth
Dillman Wolfgang
He Huaping
Hoshijima Masahiko
Meyer Markus
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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