C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C12N 5/02 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2546942
The present invention relates to methods for isolating infrequently-dividing, slow-cycling cells, a feature which is typical of stem cells in their niche. The methods of the present invention are advantageously used as classical stem cells can be isolated. Further provided are methods for generating clonal populations and inhibiting the differentiation of these cells. In addition markers for distinguishing these cells from progenitor cells are also disclosed.
La présente invention concerne des procédés permettant d'isoler des cellules à cycle lent et se divisant peu fréquemment, caractéristique typique des cellules souches dans leur niche. Les procédés de l'invention conviennent de façon intéressante dans la mesure où les cellules souches classiques peuvent être isolées. L'invention concerne également des procédés permettant de générer des populations clonales et d'inhiber la différentiation de ces cellules. L'invention concerne enfin des marqueurs permettant de repérer ces cellules parmi les cellules progénitrices.
Blanpain Cedrick
Fuchs Elaine
Lowry William E.
Tumbar Tudorita
Borden Ladner Gervais Llp
The Rockefeller University
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