A method for isolating and purifying 90y from 90strontium in...

G - Physics – 21 – F

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G21F 9/00 (2006.01) G21G 4/08 (2006.01)

Patent

CA 2406400

The invention relates to a process for separating and purifying multi-curie quantities 90Y of sufficient chemical and radiochemical purity suitable for use in medical applications without a series of 90Sr selective extraction chromatographic columns while minimizing loss of radioactive 90Sr parent and waste stream. The process includes dissolving a nitrate salt of an original 90Sr stock solution in H2O creating a strontium nitrate solution; acidifying the strontium nitrate solution containing 90Y with concentrated nitric acid; evaporating the strontium nitrate solution; filtering or centrifuging strontium nitrate solution to separate crystalline 90Sr nitrate salt from the solution; evaporating the remaining 90Y enriched supernate to dryness; dissolving the remaining 90Y enriched supernate in a strong acid; passing the solution through an yttrium selective extraction chromatographic column; rinsing the yttrium selective extraction chromatographic column with strong acid; and eluting yttrium from yttrium selective extraction column with strong acid.

L'invention concerne un procédé de séparation et de purification de quantités multi-curies de <90>Y d'une pureté chimique et radiochimique suffisante afin d'être utilisées dans des applications médicales sans nécessiter une série de colonnes de chromatographie d'extraction sélective de <90>Sr, tout en minimisant la perte de composé apparenté au <90>Sr ou flux de déchets radioactifs <90>Sr. Le procédé consiste à dissoudre un nitrate d'une solution-mère <90>Sr dans H2O, créant une solution de nitrate de strontium; à acidifier la solution de nitrate de strontium renfermant <90>Y avec de l'acide nitrique concentré; à évaporer la solution de nitrate de strontium; à filtrer ou centrifuger la solution de nitrate de strontium en vue de séparer le nitrate cristallisé <90>Sr de la solution; à évaporer à sec le reste du surnageant enrichi en <90>Y; à dissoudre le reste du surnageant enrichi en <90>Y dans un acide fort; à passer la solution dans une colonne de chromatographie d'extraction sélective d'yttrium; à rincer cette colonne au moyen d'un acide fort et à éluer l'yttrium de cette colonne au moyen d'un acide fort.

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