A method for minimizing the uterotrophic effect of tamoxifen...

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 31/21 (2006.01) A61K 31/25 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2200205

The present invention provides a method of minimizing the uterotrophic effect of non-steroidal triphenylethylene, antiestrogenic compounds, when such compounds are administered for the treatment or prevention of breast carcinoma, via the coadministration of certain antiestrogenic naphthyl compounds. Pharmaceutical compositions are also provided.

L'invention concerne un procédé permettant de minimiser l'effet utérotrophique de composés anti-oestrogéniques non stéroïdaux à base de triphényléthylène quand ils sont administrés pour traiter ou prévenir le cancer du sein, grâce à la co-administration de certains composés anti-oestrogéniques à base de naphtyle. On décrit aussi des compositions pharmaceutiques appropriées.

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