A method for monitoring the progress of cancer

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2562835

The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of prostate cancer in a mammal. The present invention more specifically provides a method for delineating early stage and advanced stage cancers, or predispositions thereto, by screening for changes in the level of two or more of inhibin-.alpha., activin-.beta.A, activin-.beta.B, activin-.beta.C, activin- .beta.D, activin-.beta.E or follistatin expression in a mammal. The present invention further provides a method for diagnosing or monitoring conditions associated with or characterized by the onset of a cancer.

L'invention concerne, de façon générale, un procédé de diagnostic, de prédiction ou de régulation du développement ou de la progression d'un cancer, et plus particulièrement, un procédé de diagnostic, de prédiction ou de régulation du développement ou du progrès d'un cancer de la prostate chez un mammifère. Cette invention concerne, plus spécifiquement, un procédé destiné à repérer les cancers en stade précoce et en stade avancé, ou des prédispositions aux cancers, par criblage de changements dans le niveau de deux ou plusieurs expressions d'inhibine-.alpha., d'activine-.beta.<SB>A</SB>, d'activine-.beta.<SB>B</SB>, d'activine-.beta.<SB>C</SB>, d'activine-.beta.<SB>D</SB>, d'activine-.beta.<SB>E</SB> ou de follistatine chez un mammifère. Cette invention concerne également un procédé destiné à diagnostiquer ou à réguler des états associés ou caractérisés par l'apparition d'un cancer.

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