A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/145 (2006.01) A61K 39/39 (2006.01) A61K 9/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2451091
The present invention discloses a method for an efficient entrapment of active biological material in liposomes. The method is based on the steps of drying a suspension of liposome-forming lipids and then hydrating the dry composition obtained with an aqueous solution containing a biologically active material to be entrapped in high yield in the liposomes thus formed. The invention also concerns liposomal formulations produced by the method of the invention and their uses.
L'invention concerne une méthode permettant de piéger efficacement un matériau biologique actif dans des liposomes. Ladite méthode consiste à sécher une suspension de lipides formant des liposomes, puis à hydrater la composition sèche obtenue à l'aide d'une solution aqueuse contenant le matériau biologique actif à piéger à des niveaux élevés dans les liposomes ainsi formés. L'invention concerne également des formulations liposomales produites à moyen dudit procédé et leurs utilisations.
Barenholz Yechezkel
Joseph Aviva
Kedar Eliezer
Borden Ladner Gervais Llp
Yissum Research Development Company Of The Hebrew University In
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