A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2609572
The present invention relates to antigenic heterocomplexes of TNF-alpha and a carrier protein for obtaining a humoral immune response in a mammal with production of antibodies that neutralize the biological activity of TNF-alpha as well as to a method for preparing the same. The antigenic protein TNF-alpha and the carrier protein are conjugated in presence of EDTA using glutaraldehyde , formaldehyde and glycine and, in some embodiments, DMSO, allowing thus to improve immunogenicity and stability. The following proteins can be used as carrier: keyhole limpet Haemocyanin (KHL) , bovine serum albumins (BSA) , inactivated bacterial toxins such as tetanus or diphteria toxins (TT and DT) , the purified protein derivative of tuberculin (PPD) and Protein D from Haemophilus Influenzae .
La présente invention concerne un nouveau procédé de préparation d'un produit immunogène stable comprenant des hétérocomplexes antigéniques de TNF.alpha. et une protéine-support, les étapes de ce procédé étant présentées dans la spécification.
Le Buanec Helene
Zagury Daniel
Gowling Lafleur Henderson Llp
Neovacs
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