A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 31/192 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01)
Patent
CA 2706379
The invention relates to a method for producing an adapalene aqueous gel, which method comprises preparing a gelling medium A by mixing water and propylene glycol and adding a gelling agent; preparing an adapalene medium B by dispersing adapalene in water, in the presence of a surfactant; adding the adapalene medium B to the gelling medium A; and adjusting the pH to about 4.7-5.3.
L'invention concerne un procédé de fabrication d'un gel aqueux d'adapalène. Le procédé selon l'invention comprend la préparation d'un milieu gélifiant A par mélange d'eau et de propylène glycol et ajout d'un agent gélifiant ; la préparation d'un milieu d'adapalène B par dispersion d'adapalène dans de l'eau, en présence d'un tensioactif ; l'ajout du milieu d'adapalène B au milieu gélifiant A ; et l'ajustement du pH à environ 4,7-5,3.
Dugat Richard
Ebel Maurice
Galderma Research & Development
Robic
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