A method for producing aminopyrrolidine derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/10 (2006.01) C07C 237/44 (2006.01) C07C 269/04 (2006.01) C07C 269/06 (2006.01) C07C 271/28 (2006.01)

Patent

CA 2542012

A process for industrially producing an aminopyrrolidine derivative represented by the following formula, which has antagonistic activity against a chemokine receptor; an intermediate; and a process for producing the intermediate. (I) (R11 is hydrogen, C1-6 alkyl, or C2-7 alkanoyl; R12, R14, R15, R16, and R17 each is hydrogen, halogeno, optionally halogenated C1-6 alkyl, optionally halogenated C1-6 alkoxy, hydroxy, or C2-7 alkoxycarbonyl; R23, R24, R25, and R26 each is hydrogen, halogeno, optionally halogenated C1-6 alkyl, optionally halogenated C1-6 alkoxy, or hydroxy; and R3 is hydrogen or C1-6 alkyl.)

L'invention concerne une méthode de production d'un dérivé d'aminopyrrolidine de formule (I) présentant une activité antagoniste contre un récepteur de la chémokine. Elle concerne un intermédiaire, et une méthode de production de l'intermédiaire. Dans ladite formule, R?11¿ est hydrogène, alkyle C¿1-6?, ou alcanoyle C¿2-7?; R?12¿, R?14¿, R?15¿, R?16¿ et R?17¿ sont chacun hydrogène, halogéno, alkyle C¿1-6? éventuellement halogéné, alcoxy C¿1-6? éventuellement halogéné, hydroxy, ou alcoxycarbonyle C¿2-7?; R?23¿, R?24¿, R?25¿ et R?26¿ sont chacun hydrogène, halogéno, alkyle C¿1-6? éventuellement halogéné, alcoxy C¿1-6? éventuellement halogéné, ou hydroxy; et R?3¿ est hydrogène ou alkyle C¿1-6?.

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