A method for screening compounds for their potential to...

A - Human Necessities – 61 – K

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A61K 31/192 (2006.01) A61K 31/165 (2006.01) A61K 31/4409 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2335397

This invention provides a method to identify compounds potentially useful for the treatment and prevention of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with its ability to elevate JNK kinase activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibition, an ability to elevate JNK kinase activity, growth inhibition and apoptosis induction are desirable for the treatment of neoplasia.

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