C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 35/28 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2245762
A method for the selective purging ex vivo of CD77 positive cells from bone marrow prior to autologous transplantation is described. The method involves treating the bone marrow with shiga toxin or shiga-like toxin-1 to kill CD77+ cells or to remove them by affinity chromatography. The toxin selectively binds to CD77+ cells and not to other bone marrow cells. The method offers a means for curing non-Hodgkin's lymphomas.
La présente invention concerne un procédé d'élimination sélective ex vivo de cellules CD77 positives de la moëlle osseuse avant une greffe autologue de moëlle osseuse. Ce procédé comprend le traitement de la moëlle avec la toxine shiga ou la toxine 1 analogue à la toxine shiga pour tuer les cellules CD77?+¿ ou pour les éliminer par chromatographie par affinité. La toxine se fixe de manière sélective sur les cellules CD77?+¿ et pas sur d'autres cellules de la moëlle osseuse. Ce procédé offre un moyen de guérir les lymphomes autres que celui de Hodgkin.
Ridout & Maybee Llp
The Ontario Cancer Institute
LandOfFree
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