C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/79 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2722998
The present invention relates to a method for improving expression of two or more proteins in a (host) cell. The method is suited for production of for example recombinant antibodies that can be used in a pharmaceutical preparation or as a diagnostic tool. In one embodiment, the invention provides a method for obtaining a cell which expresses two or more proteins comprising providing said cell with two or more protein expression units encoding said two or more proteins, characterised in that at least two of said protein expression units comprise at least one STAR sequence wherin said STAR sequence protects said transgenes from the effect of gene silencing.
Kruckeberg Arthur Leo
Otte Arie Pieter
Sewalt Richard George Antonius Bernardus
Borden Ladner Gervais Llp
Chromagenics B.v.
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