A method for testing drugs for maintaining, preventing, loss...

Details A method for testing drugs for maintaining, preventing, loss... A method for testing drugs for maintaining, preventing, loss...

C - Chemistry, Metallurgy

12

Q

C12Q 1/26 (2006.01) A61K 31/135 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2329569

41 ABSTRACT The present invention relates to a method for testing a drug for activity in maintaining, preventing loss and/or recovering nerve cell function in a patient. The method comprises (A) administering an agent having neurotoxic activity to a test animal; administering the drug to the said animal; sacrificing the test animal within a period of 20 days from completion of administration of the agent; taking brain serial sections through the substantia nigra compacta of the test animal; determining the number of serial sections of the brain taken through the substantia nigra compacta; staining the serial sections of the brain to determine the number of Nissl stained positive substantia nigra compacta and tyrosine hydroxylase positive somata in intervening serial sections; and (B) comparing the number of tyrosine hydroxlyase positive somata and Nissl stained somata determined, with the number of tyrosine hydroxlyase positive somata and Nissl stained somata in serial sections of a brain through the substantia nigra compacta of a control animal which has not been administered the drug wherein any difference in staining indicates said drugs activity in maintaining, preventing, loss and/or recovering nerve cell function in a patient.

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