A method for the acylation of the 7-amino group of the...

C - Chemistry – Metallurgy – 12 – P

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C12P 35/04 (2006.01) C07D 277/46 (2006.01) C07D 501/00 (2006.01) C07D 501/34 (2006.01) C07D 501/36 (2006.01)

Patent

CA 2103696

ABSTRACT A method for the acylation of the 7-amino group of the cephalosporanic ring, according to which a 7-ACA amino thiazolyl protected adduct is prepared by acylating said amino group by an aminothiazolyl acetic acid whose amino group has been protected by a phenyl acetyl or a phenoxy acetyl group, the amino group being then deprotected by aqueous hydrolysis in the presence of penicillin G amidase or respectively penicillin V amidase.

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