A method for the establishment of a pluripotent human...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/0735 (2010.01) C12N 5/071 (2010.01) A61K 35/54 (2006.01) A61P 5/48 (2006.01) A61P 25/28 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2471540

The present invention concerns a method for the establishment of pluripotent human blastocyst-derived stem (BS) cell line, stem cells obtained by the method, differentiation of these cells into differentiated cells, the differentiated cells and the use of these differentiated cells in the preparation of medicaments. The undifferentiated pluripotent stem cells can be made to differentiate to a number of specialized cell types which can be utilized in the manufacture of medicaments for treating a number of conditions or pathologies involving degeneration of tissue e.g. of the pancreas leading to e.g. development of diabetes, or of the CNS (e.g. Alzheimer's, Parkinson's disease etc.) or degeneration of the CNS caused by e.g. stroke or physical trauma.

L'invention concerne une méthode permettant d'établir une lignée de cellules souches hématopoïétiques multipotentes humaines dérivées du blastocyste (BS), des cellules souches obtenues au moyen de ce procédé, la différenciation de ces cellules, des cellules différenciées et l'utilisation de ces cellules différenciées dans la préparation de médicaments. Les cellules souches multipotentes non différenciées peuvent permettre de différencier un certain nombre de types cellulaires spécialisés qui peuvent être utilisés dans la fabrication de médicaments destinés au traitement d'un certain nombre d'affections ou d'états pathologiques entraînant la dégénérescence de tissus, par exemple, du pancréas, ce qui entraîne, par exemple, un développement du diabète, ou la dégénérescence du système nerveux central (par exemple, la maladie d'Alzheimer, la maladie de Parkinson, etc.) ou du système nerveux central suite, par exemple, à un accident vasculaire cérébral ou à un traumatisme physique.

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