A method for the high level expression of active...

Details A method for the high level expression of active... A method for the high level expression of active...

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 38/00 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2354539

The invention relates to methods for the expression of high yields of the form protein-immunoglobulin fusions having high affinity binding to its ligand, by culturing hosts transformed with DNA encoding the desired fusions in a cultutre system at a low temperature thereby minimizing the amount of misfolded or misbridged protein forms. Said host cells may be transformed mammalian, insect, yeast or bacterial cells. The protein-immunoglobulin fusion may comprises a member of the TNF or TNF-receptor family, such as lymphotoxin- beta or lymphotoxin-beta receptor. The invention also relates to pharmaceutical composition comprising said protein-immunoglobulin fusions.

L'invention concerne une méthode qui permet d'obtenir un haut niveau d'expression de protéines chimères immunoglobulines actives réceptrices de la lymphotoxine-bêta. L'invention concerne également une méthode purification desdites protéines.

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