G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/573 (2006.01)
Patent
CA 2535649
The present invention relates to a method for the identification of an IRS protein kinase inhibitor, comprising the steps of a) bringing into contact PKC- .zeta. with at least one IRS peptide comprising at least one PKC-.zeta.-Ser- phosphorylation site in the presence of at least one putative inhibitor, and b) measuring the phosphorylation of the PKC-.zeta.-Ser-phosphorylation site.
La présente invention concerne un procédé destiné à l'identification d'un inhibiteur de protéine kinase IRS qui consiste en ce qui suit a) mettre en contact PKC-? avec au moins un peptide IRS comprenant au moins un site de PKC-?-Ser-phosphorylation en présence d'au moins un inhibiteur présumé et b) mesurer la phosphorylation du site de PKC-?-Ser-phosphorylation.
Eckel Juergen
Metzger Sabine
Sommerfeld Mark
Tennagels Norbert
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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