A method for the mass production of immunoglobulin fc region...

Details A method for the mass production of immunoglobulin fc region... A method for the mass production of immunoglobulin fc region...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01)

Patent

CA 2619771

Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin Fc region linked at the N-terminus thereof to an immunoglobulin Fc region via a peptide bond.

L'invention concerne un procédé pour la production en masse d'une région Fc d'immunoglobuline monomère ou dimère, libre de résidus de méthionine initiale en utilisant un vecteur d'expression recombinante comportant une codification par séquence nucléotidique pour une région Fc d'immunoglobuline recombinante comprenant une région Fc d~immunoglobuline liée à son N-terminus à une région Fc d'immunoglobuline via une liaison peptidique.

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