A method for the preparation of a substrate for immobilising...

C - Chemistry – Metallurgy – 08 – J

Patent

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Details

C08J 7/18 (2006.01) B05D 7/02 (2006.01) B05D 7/24 (2006.01) C03C 17/32 (2006.01) C03C 17/34 (2006.01) C08F 2/34 (2006.01) C08F 2/52 (2006.01) C08F 220/06 (2006.01) C08F 220/32 (2006.01) C08J 3/24 (2006.01) C12Q 1/68 (2006.01) C23C 8/36 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2436253

The invention relates to a method of providing a solid substrate for immobilising chemical compounds particular biomolecules. The method comprises the steps of providing a basis substrate, and treating the surface of the basis substrate with a monomer gas in a plasma generated by a power source selected from the group consisting of multiple phase AC supply and multiple DC supply, wherein the intensity of said plasma being at the most 5.0 W/I, such as at the most 3.0 W/I, and said monomer gas comprising one or more types of monomers which is plasma polymerised onto the surface to thereby provide the surface of the solid substrate with chemically reactive groups. The invention also relates to a substrate obtainable by the method, and a process for immobilising a chemical compound to a surface of such solid substrate. The method is relatively simple and economically feasibly, and the substrate has a high quality and a high concentration of functionalities.

L'invention concerne un procédé permettant de fournir un substrat solide destiné à immobiliser des composés chimiques, notamment des biomolécules. Le procédé consiste à fournir un substrat de base et à en traiter la surface au moyen d'un gaz monomère dans un plasma généré par une source d'énergie sélectionnée dans le groupe constitué par une alimentation CA à phases multiples et une alimentation CC à phases multiples, l'intensité dudit plasma étant au maximum de 5,0 W/I ou de 3,0 W/I, et ledit gaz monomère comprenant un ou plusieurs types de monomères polymérisés au plasma sur la surface afin de fournir à la surface du substrat solide des groupes chimiquement réactifs. L'invention concerne également un substrat pouvant s'obtenir selon le procédé et un processus d'immobilisation d'un composé chimique à la surface dudit substrat solide. Le procédé est relativement simple et économiquement réalisable, le substrat est d'une grande qualité et présente une concentration élevée de fonctionnalités.

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