C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 217/04 (2006.01) C07C 309/20 (2006.01) C07D 217/02 (2006.01) C07D 217/06 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C08F 8/34 (2006.01)
Patent
CA 2300088
The invention relates to a compound of formula (I) wherein Y is the fraction of a solid or soluble support, where Y may include a residue of a functional group having been attached to said support, said functional group having been hydroxy, amino, thio, epoxy or halogen, R1 is aryl, heteroaryl, alkyl chain or ring or ring system, which may include a heteroatom, or R1 is nothing, and R2 is vinyl; CH2CH2X, where X is halogen; or R3C=CHR4 or R3CH-CH2R4X, where R3 and R4 are the same or different and are alkyl, acyl, carbonyl, cyano or nitro groups and X is halogen. The invention also relates to a method for preparation of compound (I) and to its use as a substrate in the synthesis of tertiary amines. The invention still concerns a group of alpha-2-receptor active tetrahydroisoquinoline derivatives.
L'invention concerne un composé de formule (I), dans laquelle Y est la fraction d'un support solide ou soluble, Y pouvant renfermer un reste d'un groupe fonctionnel fixé à ce support, ce groupe fonctionnel étant hydroxy, amino, thio, époxy, ou halogène, R?1¿ est une chaîne, un cycle, ou un système cyclique alkylé(e), aryl(é)e, hétéroaryl(é)e, pouvant renfermer un hétéroatome, ou R?1¿ n'est rien, et R?2¿ est vinyle; CH¿2?CH¿2?X, X étant halogène; ou R?3¿C=CHR?4¿ ou R?3¿CH-CH¿2?R?4¿X, R?3¿ et R?4¿ étant identiques ou différents et sont des groupes alkyles, acyles, carbonyles, cyano, ou nitro, X étant halogène. Cette invention concerne également un procédé de préparation de ce composé de formule (I), ainsi que son utilisation en tant que substrat dans la synthèse d'amines tertiaires. Cette invention concerne enfin un groupe de dérivés de tétrahydro-isoquinoléine actifs comme alpha-2-récepteurs.
Cockcroft Victor
Heinonen Petri
Lonnberg Harri
Savola Juha-Matti
Oy Juvantia Pharma Ltd.
Robic
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