A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/352 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/4704 (2006.01) A61K 31/4709 (2006.01)
Patent
CA 2311932
A method for the prevention and treatment of stunning of the heart subsequent to ischemia-reperfusion is described. The method comprises administering a therapeutically effective amount of a phospholamban inhibitor to a patient. Phospholamban inhibitors relieve the inhibitory effect of phospholamban on cardiac sarcoplasmic reticulum Ca2+-ATPase.
La présente invention concerne une méthode de prévention et de traitement de la sidération myocardique consécutive à une reperfusion après ischémie. Cette méthode consiste à administrer à un patient une quantité thérapeutiquement efficace d'un inhibiteur phospholambanique. Les inhibiteurs phospholambaniques réduisent l'effet inhibiteur du phospholamban sur CA?2+¿-ATPase du réticulum sarcoplasmique cardiaque.
Haikala Heimo
Kaheinen Petri
Kaivola Juha
Levijoki Jouko
Ovaska Martti
Orion Corporation
Robic
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