A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/425 (2006.01) A61K 31/428 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2372077
The present invention pertains to a method for the reduction of glutamate neurotoxicity in pathophysiology of spinal cord injury induced by aortic cross- clamping. The reduction is achieved by the administration of riluzole to a patient, in an amount effective to reduce glutamate neurotoxicity, contemporaneously with aortic cross-clamping. Preferably, the riluzole is administered both prior to and following the aortic cross-clamping. The method is also applicable to reduce the spinal cord injury resulting from ischemia, and for reducing the effects of ischemia on neuronal tissues.
L'invention concerne une méthode conçue pour réduire la neurotoxicité en glutamate dans la pathophysiologie des lésions de la moelle épinière causées par le clampage total de l'aorte. Le riluzole est administré de préférence, à la fois avant et après le clampage total de l'aorte. La méthode peut aussi être employée dans le but de réduire les lésions de la moelle épinière causées par ischémie et également pour réduire les effets de l'ischémie sur les tissus neuronaux.
Heurteaux Catherine
Lang-Lazdunski Loic
Lazdunski Michel
Centre National de La Recherche Scientifique (c.n.r.s.)
Gowling Lafleur Henderson Llp
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