A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/14 (2006.01) A61K 31/513 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2685842
The invention is based on the surprising finding that treatment with a chemotrerapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and prevent the recovery following drug withdrawal, of cancer cells. In vivo, drug resistance from a failure to adequately engage in apoptotic programmed cell death leads to a recurrence of cancer and tumours can remain dormant for periods of time before re-emerging as drug resistant metastases. It has been hypothesised that autophagy (Type II cell death) may help cancer cells survive in response to growth limiting conditions, such as nutrient depletion, hypoxia, absence of growth factor, or presence of cytotoxic drug. LiCl is a known autophagy inducer and accelerates cell survival to autophagic programmed cell death.
Mckenna Sharon
O'donovan Tracey
O'sullivan Gerald C.
Cork University College Cork National University Of Ireland
Kirby Eades Gale Baker
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