A method for the treatment or prevention of bone erosion

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 31/00 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2458993

There is provided a method for the treatment or prevention of bone erosion caused by a disease that activates osteoclasts (e.g. rheumatoid arthritis) comprising administering to a patient an anti-human Fas monoclonal antibody HFE7A or a humanized version thereof, as well as a composition for use in such a method. There is also provided a method for testing a substance for the treatment or prevention of bone erosion comprising: transplanting pieces of dentine and synovial tissue from a patient suffering from a disease that activates osteoclasts to immunodeficient non-human mammals; administering the substance to be tested to at least one of the test animals and a control to at least one different test animal and breeding them; and then extracting said pieces of dentine from the test animals and counting the number of resorption pits formed on the surface of each piece that was in contact with said sample of synovial tissue.

La présente invention concerne une technique de traitement ou de prévention de l'érosion osseuse induite par une maladie qui active des ostéoclastes ( par exemple l'arthrite rhumatoïde). Cette technique consiste à administrer à un patient un anticorps monoclonal anti-Fas humain HFE/A ou une version humanisée de celui-ci. Cette invention concerne aussi une composition convenant pour cette technique. Cette invention concerne encore une technique permettant de tester une substance destinée au traitement ou à la prévention de l'érosion osseuse qui consiste à transplanter des morceaux de dentine et un tissu synovial prélevé sur un patient atteint d'une maladie qui active les ostéoclastes sur des mammifères non humains immunodéficients, à administrer la substance à tester à au moins un des animaux test et une substance de contrôle à au moins un animal test différent et à les élever, puis à extraire ces morceaux de dentine des animaux testés et à compter le nombre de puits de résorption formés à la surface de chaque morceau qui a été en contact avec le prélèvement de tissu synovial.

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