A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/48 (2006.01) A61J 3/07 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01)
Patent
CA 2191709
Capsules (such as hard gelatin, cellulose and plastic capsules) containing pharmaceutical powders which are administered to a patient via inhalation are treated so as to increase the effective amount of the pharmaceutical agent reaching the respiratory system of the patient. The capsules are coated internally with a lubricant during manufacture and in one aspect, the method involves exposing the lubricant-coated inner surface of the capsule to a pharmaceutically acceptable solvent which dissolves the lubricant. Generally, the solvent is volatile, and bactericidal (e.g. ethanol). The pharmaceutical powder is inserted in the capsule following this washing procedure. Alternatively, the lubricant-coated capsule is dusted internally with a dusting agent such as a salt (e.g. sodium chloride) or a sugar (e.g. lactose, mannitol, trehalose or sucrose) prior to inserting the pharmaceutical powder inside the capsule. The invention also pertains to a capsule, optionally containing the pharmaceutical powder therein, which has been treated according to the methods discussed above.
Des capsules (par exemple en gélatine dure, cellulose ou plastique) contenant des poudres pharmaceutiques administrées à un patient par inhalation sont traitées afin d'accroître la proportion efficace d'agent pharmaceutique atteignant le système respiratoire du patient. Lors de la fabrication, l'intérieur des capsules est revêtu d'un lubrifiant. Selon un aspect de l'invention, on expose la surface interne de la capsule revêtue de lubrifiant à un solvant pharmaceutiquement acceptable qui dissout le lubrifiant. Généralement, le solvant est volatil et bactéricide (éthanol par ex.). La poudre pharmaceutique est introduite dans la capsule après cette étape de lavage. Selon un autre procédé, l'intérieur de la capsule revêtue de lubrifiant est saupoudré avec un agent de saupoudrage tel qu'un sel (chlorure de sodium par ex.) ou un sucre (lactose, mannitol, tréhalose ou saccharose par ex.) avant l'introduction de la poudre pharmaceutique dans la capsule. L'invention concerne également une capsule, contenant éventuellement la poudre pharmaceutique, traitée selon les procédés mentionnés ci-dessus.
Clark Andrew R.
Gonda Igor
Dennison Associates
Genentech Inc.
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