A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01)
Patent
CA 2126108
2126108 9312808 PCTABS00024 The present invention is directed to a method for arresting or inhibiting the growth of cells in Kaposi's Sarcoma lesions and a method for arresting or inhibiting the growth of the Kaposi's Sarcoma lesions, said methods comprising contacting the cells in the lesions with an effective amount of SP-PG, a naturally occuring sulfated polysaccharide-peptidoglycan produced by a specific species of the bacterium Arthrobacter, AT-25. The invention is also directed to blocking or inhibiting the activity of cellular vascular permeability factor(s), which comprises contacting vascular cells with an effective amount of SP-PG. In one embodiment, there is provided a method for blocking or inhibiting increased vascular permeability (and resulting edema) in diseases and disorders in which the increased vascular permeability contributes to the pathology, for example, in Kaposi's Sarcoma, tumorigenesis, inflammation, diabetic retinopathy, etc. Increased effectiveness is obtained when SP-PG is combined with cortisone or a cortisone derivative, such as hydrocortisone or tetrahydrocortisone.
Gallo Robert C.
Nakamura Shuji
Osada Yasuaki
Sakurada Shinsaku
Salahuddin Syed Zaki
Daiichi Pharmaceutical Co. Ltd.
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Fetherstonhaugh & Co.
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