A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/047 (2006.01) A61K 31/05 (2006.01) A61K 31/12 (2006.01) A61K 31/425 (2006.01) A61K 31/65 (2006.01) A61K 31/69 (2006.01)
Patent
CA 2488609
The present invention involves the use tethered bis(polyhydroxyphenyl) compounds to slow the progression of neurological diseases in which pro- inflammatory cytokine stimulation of microglial cells is reasonably anticipated to make a significant contribution to disease pathology. Diseases for which this is the case include amyotrophic lateral sclerosis (AlS) and other motor neuron diseases (MNDs) of similar clinical presentation; Parkinson~s disease (PD); Alzheimer~s disease (AD); spino-bulbar atrophy; (SBA); Huntington~s disease (HD); myasthenia gravis (MG); multiple sclerosis (MS); HIV-associated dementia; fronto-temporal dementia (FTD); stroke; encephalomyelitis; traumatic brain injury; age-related retinal degeneration; and other neurological diseases possessing microglial activation as a contributing pathological feature. Specific examples are presented where the tethered bis(polyhydroxyphenyl) compound is resveratrol; piceatannol; nordihydroguaiaretic acid (NDGA), curcumin, or sesamin.
L'invention concerne l'utilisation de composés bis(polyhydroxyphényles) fixés pour ralentir la progression de maladies neurologiques dans lesquelles la stimulation de cytokine pro-inflammatoire des cellules microgliales est prise avec une anticipation raisonnable, ce qui permet d'apporter une contribution importante à la pathologie concernée. Les maladies visées sont les suivantes: sclérose latérale amyotrophique et autres maladies du motoneurone ayant les mêmes caractéristiques cliniques; maladie de Parkinson; maladie d'Alzheimer; atrophie spino-bulbaire; maladie de Huntington; myasthenia gravis; sclérose en plaques; démence associée au VIH; démence fronto-temporale; accident vasculaire cérébral; encéphalomyélite; traumatisme cérébral; dégénérescence rétinienne liée à la vieillesse, et autres maladies neurologiques à activation microgliale intervenant comme contribution pathologique. On donne dans l'invention des exemples spécifiques de composés bis(polyhydroxyphényles) fixés, à savoir: resvératrol; picéatannol; acide nordihydroguaïrétique curcumine ou sésamine.
Floyd Robert A.
Hensley Kenneth L.
Goudreau Gage Dubuc
Oklahoma Medical Research Foundation
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