C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) B01D 15/32 (2006.01) B01D 15/36 (2006.01) B01J 41/04 (2006.01) C07K 1/14 (2006.01) C07K 1/34 (2006.01) C07K 1/36 (2006.01)
Patent
CA 2582113
The present invention relates to a method of separating antibodies from other compound(s) in a liquid sample, wherein a mobile phase comprising said sample is contacted with a multi-modal separation matrix to adsorb undesired compounds while the antibodies remain free in the liquid, wherein the multi- modal separation matrix comprises first groups, which are capable of interacting with negatively charged sites of the target compounds, and second groups, which are capable of at least one interaction other than charge-charge interaction with said target compounds. The invention also relates to a chromatography column packed with the above-described multi-modal separation matrix and a filter having such multi-modal groups adsorbed to its surface
L'invention concerne un procédé de séparation d'anticorps d'un ou de plusieurs autres composés dans un échantillon liquide, procédé dans lequel une phase mobile comprenant ledit échantillon est mise en contact avec une matrice de séparation multimodale pour adsorber des composés indésirables, tandis que les anticorps demeurent libres dans le liquide. Le procédé est caractérisé en ce que la matrice de séparation multimodale comprend des premiers groupes capables d'interaction avec des sites, chargés négativement, des composés cibles, et des seconds groupes capables d'au moins une interaction, autre qu'une interaction entre charges avec lesdits composés cibles. L'invention concerne également une colonne de chromatographie garnie de la matrice de séparation multimodale et d'un filtre ayant de tels groupes multimodaux adsorbés à sa surface.
Engstrand Carina
Forss Annika
Glad Gunnar
Johansson Bo-Lennart
Johansson Hans J.
Fetherstonhaugh & Co.
Ge Healthcare Bio-Sciences Ab
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