A method of assessing risk for cardiovascular disease and...

A - Human Necessities – 61 – K

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A61K 31/575 (2006.01) C12Q 1/60 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2259519

A method of determining in an animal the ratio of serum campesterol to the level of beta-sitosterol comprises the steps of taking a serum sample, determining the campesterol level therein, determining the beta-sitosterol level therein, dividing the campesterol level by the beta-sitosterol level to form a campesterol/beta-sitosterol ratio, and comparing the campesterol/beta- sitosterol ratio with that of a normal control, wherein the improvement comprises selecting the campesterol/beta-sitosterol ratio as an indicator and correlating the ratio to the risk of the animal having an increased risk of cardiovascular and related diseases.

Les étapes d'un procédé permettant de déterminer le rapport du taux de campestérol sérique au taux de bêta-sitostérol chez un animal consistent à prendre un échantillon de sérum, établir le taux de bêta-sitostérol contenu dans ledit échantillon, diviser le taux de campestérol sérique par le taux de bêta-sitostérol pour obtenir un rapport campestérol/bêta-sitostérol et comparer ledit rapport campestérol/bêta-sitostérol avec celui d'un contrôle indiciaire normal. L'amélioration dans le procédé consiste à sélectionner le rapport campestérol/bêta-sitostérol comme indicateur et comparer ledit rapport avec la probabilité d'un risque accru d'une maladie cardiovasculaire ou apparentée chez l'animal.

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