A method of assessing the biological status of cancer...

Details A method of assessing the biological status of cancer... A method of assessing the biological status of cancer...

G - Physics

01

N

G01N 33/574 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2299210

This invention provides a method for indicating a high or low risk of developing cancer at specific sites along the colon, according to a model of carcinogenesis and measurements of activated enterocytes. The method determines the presence and the intensity of a "promoting environment," a region of intestinal epithelial cells which are biochemically programmed as activated enterocytes to develop cancer in response to certain signals. The model predicts that cancer can develop only in such an environment when the promoting influence is sufficiently intense. If cancer is determined to be present, this method enables one to assess the stage of cancer, which can be used to monitor the effectiveness of therapeutic regimes during the course of treatment for a patient. The method can also be used in the field of cancer research to develop understanding of the etiology of the disease in addition to new treatments for cancer therapy.

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