A method of cell isolation

Details A method of cell isolation A method of cell isolation

G - Physics

01

N

G01N 33/50 (2006.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) C12Q 1/04 (2006.01)

Patent

CA 2566549

The present invention relates generally to a method for the generation of a substantially homogenous population of undifferentiated cells. More particularly, the present invention relates to a method for isolating a substantially homogenous population of stem cells, and in particular, mammary stem cells (MaSCs). The MaSCs of the present invention are isolated on the basis of differential levels of proteins present on their cell surface. The MaSCs of the present invention are particularly useful as targets for identifying agents which modulate MaSC survival, self-renewal, proliferation and/or differentiation in both normal and diseased tissue such as, but not limited to, tumor tissue, and, also as source of tissue for the regeneration, replacement and/or augmentation of tissue damaged and/or lost after disease or injury.

La présente invention a trait à un procédé pour la génération d'une population sensiblement homogène de cellules non différenciées. Plus particulièrement, la présente invention a trait à un procédé pour l'isolement d'une population sensiblement homogène de cellules souches, et notamment des cellules souches mammaires. Les cellules souches mammaires de la présente invention sont isolées sur la base de différents niveaux de protéines présentes à leur surface cellulaire. Les cellules souches mammaires de la présente invention sont particulièrement utiles comme cibles pour l'identification d'agents modulateurs de la survie, le renouvellement autonome, la prolifération et/ou la différenciation des cellules souches mammaires tant dans du tissu sain que dans du tissu malade, tel que, mais de manière non exclusive, le tissu tumoral, et, également en tant que source de tissu pour la génération, le remplacement et/ou l'accroissement de tissu endommagé et/ou détruit suite à une maladie ou une lésion.

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