C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/55 (2006.01) C07K 14/755 (2006.01)
Patent
CA 2279494
The invention concerns a method of chromatographically purifying or fractionating von Willebrand factor (vWF) from a vWF-containing starter material, the method comprising the following steps: adsorption of the vWF from the starter material on avid collagen immobilized on a carrier; separation of the non-absorbed part and optionally washing of the carrier; elution of the vWF from the immobilized collagen; and extraction of the purified vWF. The invention also concerns a pharmaceutical preparation comprising biologically active vWF which is stably bonded to collagen.
L'invention concerne un procédé de purification et de fractionnement chromatographique du facteur Willebrand (vWF) contenu dans un matériau de départ, qui comprend les étapes suivantes: absorption du vWF contenu dans le matériau de départ en collagène avide immobilisé sur un support; séparation de la part non absorbante et éventuellement lavage du support; élution du vWF hors du collagène immobilisé et extraction du vWF purifié. L'invention concerne également une préparation pharmaceutique comprenant du vWF biologiquement actif, lié de manière stable au collagène.
Dorner Friedrich
Eibl Johann
Fischer Bernhard
Mitterer Artur
Schwarz Hans-Peter
Baxter Aktiengesellschaft
Fetherstonhaugh & Co.
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