A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2324865
The present invention relates to methods for detecting interactions between two proteins as well as detecting the modulation of those interactions. The present invention is based upon the discovery of a new non-nuclear system utilizing G protein gamma subunit fusions to detect the interactions between two proteins and is particularly useful for the detection of the interaction between two or more proteins wherein one of the proteins is associated with the cell membrane. Related methods, compositions and kits can be used to detect or assay the interactions between essentially any two proteins that can be expressed in a cell.
L'invention a trait à des procédés servant à détecter des interactions entre deux protéines, ainsi que la modulation de ces interactions. L'invention repose sur la découverte d'un nouveau système non nucléaire utilisant des fusions de sous-unités gamma de protéine G pour détecter les interactions entre deux protéines, et est particulièrement utile pour détecter une interaction entre deux ou davantage de protéines lorsqu'une des protéines est associée à la membrane cellulaire. Des procédés, des compositions et des trousses associés peuvent être utilisés pour détecter ou tester les interactions entre essentiellement deux protéines, quelles qu'elles soient, pouvant être exprimées dans une cellule.
Dohlman Henrik G.
Ehrhard Kathleen N.
Gowling Lafleur Henderson Llp
Yale University
LandOfFree
A method of detecting drug-receptor and protein-protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with A method of detecting drug-receptor and protein-protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and A method of detecting drug-receptor and protein-protein... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1831364