G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/569 (2006.01) G01N 27/447 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2250715
This invention provides improved assays for the detection of transmissible spongiform encephalopathies (TSEs) in humans and non-human mammals. The methods involve detecting the presence or absence of 14-3-3 proteins in cerebrospinal fluid from the tested organism. Elevated levels of 14-3-3 are indicative of transmissible spongiform encephalopathies, in particular Creutzfeldt-Jacob disease in humans or mad cow disease in bovines.
La présente méthode propose des tests améliorés permettant de détecter les encéphalopathies spongiformes transmissibles chez l'homme et chez d'autres mammifères. La méthode inclut la détection de la présence ou de l'absence de protéines 14-3-3 dans le liquide céphalo-rachidien de l'organisme soumis au test. Des niveaux élevés de 14-3-3 indiquent la présence des encéphalopathies spongiformes transmissibles, en particulier de la maladie Creutzfeld-Jacob chez l'homme ou de la maladie de la vache folle chez les bovinés.
Gibbs Clarence J.
Harrington Michael G.
Hsich Gary
Kenney Kimbra
California Institute Of Technology
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Fetherstonhaugh & Co.
LandOfFree
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