G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A01N 33/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2304555
A method of determining the presence of chronic volume dependent hypertension is provided wherein a determination is made as to whether there has been a substantial reduction in phosphorylation of the blood-derived portein or renal proximal brush border membrane protein and if such reduction exists concluding that chronic volume dependent hypertension exists in a patient. The method may advantageously be practiced by employing blood serum or blood plasma as the body specimen containing the protein in determining whether a patient has chronic volume dependent hypertension, a cellular component of the blood, such as a blood-derived protein coming from the plasma membrane of lymphocytes. The method may include subsequent therapeutic patient treatment. Related diagnostic apparatus is also provided.
L'invention concerne une méthode qui permet de déterminer l'existence d'une hypertension volume-dépendante chronique. Selon la méthode, on détermine s'il y a une diminution sensible de la phosphorylation d'une protéine sanguine spécifique identique à une protéine de membrane de la bordure en brosse proximale du rein et, si cette diminution est présente, on conclut que ladite hypertension existe chez le patient. On peut avantageusement mettre cette méthode en pratique en employant le sérum ou le plasma sanguin comme échantillon corporel contenant ladite protéine, afin de déterminer si un patient a une hypertension volume-dépendante chronique. La protéine sanguine spécifique peut provenir d'un élément cellulaire du sang, par exemple de la membrane plasmatique des lymphocytes. La méthode peut comporter ensuite le traitement du patient. L'invention concerne également un dispositif diagnostique associé.
Smart & Biggar
Tulane University
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