A method of down-regulating gene expression

Details A method of down-regulating gene expression A method of down-regulating gene expression

A - Human Necessities

61

K

A61K 31/7125 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2203652

Disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmalogical formulation comprising an oligonucleotide complementary to the gene is orally administered to an animal. The oligonucleotide administered has non-phosphodiester internucleotide linkages and includes at least one 2'-substituted ribonucleotide, the oligonucleotide inhibiting the expression of a product of the gene, thereby down-regulating the expression of the gene.

Procédé de freinage de l'expression d'un gène chez un animal consistant à lui administrer oralement une préparation pharmaceutique contenant un oligonucléotide complémentaire dudit gène. L'oligonucléotide administré présente des liaisons internucléotidiques non phosphodiestériques et comporte au moins un ribonucléotide substitué en 2'. L'oligonucléotide inhibe l'expression d'un produit du gène freinant ainsi l'expression du gène.

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