A method of generating metal chelating affinity ligands

C - Chemistry – Metallurgy – 07 – K

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C07K 1/22 (2006.01) B01D 15/08 (2006.01)

Patent

CA 2517231

The present invention relates to a method of generating polydentate metal chelating affinity ligands, which method comprises the steps of providing a cyclic scaffold comprising a carbonyl, an adjacent sulphur and a nucleophile; providing a polydentate metal chelating affinity ligand arm on each scaffold by derivatisation of said nucleophile; ring-opening of the scaffold by adding a reagent that adds more metal chelating affinity ligand arm(s) to the scaffold; and, if required, deprotecting the functionalities of the ligand arm(s) so provided. In the most preferred embodiment of the method, the ring- opening and the deprotection steps are performed in a single step.

La présente invention concerne un procédé de génération de ligands polydentates à affinité de chélation de métaux, consistant à obtenir un structure cyclique comprenant un carbonyle, un soufre adjacent et un nucléophile; à créer un bras de ligand de polydentate à affinité de chélation de métaux sur chaque structure par dérivatisation dudit nucléophile; à ouvrir le noyau de la structure par addition d'un réactif, ajoutant plus de bras de ligands à affinité de chélation de métaux dans la structure; et, si nécessaire, à déprotéger les fonctionnalités des bras de ligands obtenus. Dans le mode de réalisation préféré dudit procédé, les étapes d'ouverture de noyau et de déprotection sont exécutées au cours d'une seule étape.

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